FeMn and FeMnAg biodegradable alloys: An in vitro and in vivo investigation

FeMn and FeMnAg biodegradable alloys: An in vitro and in vivo investigation

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Iron-based biodegradable metal bone graft substitutes are in their infancy but promise to fill bone defects that arise after incidents Table/Stool such as trauma and revision arthroplasty surgery.Before clinical use however, a better understanding of their in vivo biodegradability, potential cytotoxicity and biocompatibility is required.In addition, these implants must ideally be able to resist infection, a complication of any implant surgery.In this study there was significant in vitro cytotoxicity caused by pure Fe, FeMn, FeMn1Ag and FeMn5Ag on both human foetal osteoblast (hFOB) and mouse pre-osteoblast (MC3T3-E1) cell lines.

In vivo experiments on the other hand showed no signs of ill-effect on GAERS rats with the implanted FeMn, FeMn1Ag and FeMn5Ag pins being removed largely VITAMIN D 1000IU uncorroded.All Fe-alloys showed anti-bacterial performance but most markedly so in the Ag-containing alloys, there is significant bacterial resistance in vitro.